Association between sleep quality and risk of acute exacerbation of mild and moderate chronic obstructive pulmonary disease： a community-based prospective study

Tao Lin; Qian XU; Kang WU; Hua Qiu; Ying-ying Wang; Xiao-lin Liu; Xiao-nan Wang; Ju-zhong KE; Zhi-tao LI; Xiao-dan Chen; Qing-ping Liu; Chao-wei FU; Xiao-nan Ruan; Na Wang

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Association between sleep quality and risk of acute exacerbation of mild and moderate chronic obstructive pulmonary disease： a community-based prospective study

VernacularTitle:社区轻中度慢性阻塞性肺疾病患者睡眠质量与急性加重风险关联的前瞻性研究
Author: Tao LIN ¹ ; Qian XU ² ; Kang WU ¹ ; Hua QIU ¹ ; Ying-ying WANG ² ; Xiao-lin LIU ¹ ; Xiao-nan WANG ¹ ; Ju-zhong KE ¹ ; Zhi-tao LI ¹ ; Xiao-dan CHEN ¹ ; Qing-ping LIU ¹ ; Chao-wei FU ² ; Xiao-nan RUAN ¹ ; Na WANG ²
Author Information

1. Pudong New Area Center for Disease Control and Prevention， Shanghai 200136， China
2. Pudong Preventive Medicine Research Institute of Fudan University， Shanghai 200136， China
Publication Type:Research Article
Keywords: chronic obstructive pulmonary disease; sleep quality; acute exacerbation; Pittsburgh Sleep Quality Index
From: Shanghai Journal of Preventive Medicine 2021;33(11):989-994
CountryChina
Language:Chinese
Abstract: Objective:To investigate the association between sleep quality and the risk of acute exacerbation in mild and moderate chronic obstructive pulmonary disease （COPD） patients in Pudong New Area of Shanghai. Methods:This was a prospective study involving eligible mild and moderate COPD patients from 10 communities randomly selected in Pudong New District of Shanghai. A structured questionnaire was used to collect demographic characteristics， clinical information and information on acute exacerbation. Sleep quality was assessed using the Pittsburgh Sleep Quality Index （PSQI） in Chinese. Multiple negative binomial regression was used to estimate the association between sleep quality and risk of exacerbation. Results:Altogether 212 mild/moderate COPD patients participated and completed the entire survey， of whom the majority （95.8%） were mild COPD patients， 110 persons female and over half （54.2%） over 65 years old. 32.9% of the patients had poorer sleep quality at baseline. 18.9% of the patients reported exacerbation over the past year during follow-ups. Multiple negative binomial regression suggested that increased PSQI was related to higher risk of exacerbation （RR_ad=1.12， 95%CI：1.02-1.24）， and patients with poorer sleep efficiency had a higher risk of exacerbation （RR_ad=1.66， 95%CI：1.17-5.43）. Conclusion:Poorer sleep quality is associated with a higher risk of exacerbation in community mild/moderate COPD patients， especially in those with problem of sleep efficiency. More attention to sleep disorders is warranted in community management or self-management of patients with COPD.