Brain-computer Interface and Comprehensive Training for Stroke: A Resting State Functional Magnetic Resonance Imaging Study
10.3969/j.issn.1006-9771.2020.01.014
- VernacularTitle:脑机接口综合康复训练对亚急性期脑卒中疗效的静息态功能磁共振研究
- Author:
Qiong WU
1
;
Shi-yuan REN
2
;
Zan YUE
2
;
Yun-xiang GE
3
;
Di MA
1
;
Hong-liang ZHAO
4
;
Gang LIU
2
;
Jing WANG
2
;
Yu PAN
1
;
Wei-bei DOU
3
Author Information
1. Department of Rehabilitation Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
2. Institute of Robotics and Intelligent Systems, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China
3. Department of Electronic Engineering, Tsinghua University, Beijing 100084, China
4. Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
- Publication Type:Research Article
- Keywords:
stroke;
brain-computer interface;
motor imagery;
resting state functional magnetic resonance imaging;
neural plasticity;
functional connectivity
- From:
Chinese Journal of Rehabilitation Theory and Practice
2020;26(1):77-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the topological alterations in brain functional networks following comprehensive treatment including brain-computer interface (BCI) training in subacute stroke subjects. Methods:From January, 2018 to June, 2019, 14 subacute stroke patients with moderate to severe upper limbs paralysis accepted routine physical therapy, occupational therapy and BCI training based on motor imagery, for four weeks. They were assessed with Fugl-Meyer Assessment-Upper Extremities (FMA-UE), Action Research Arm Test (ARAT) and Wolf Motor Function Test (WMFT) before and after treatment, while the functional connectivity (FC) was investigated with resting state functional magnetic resonance imaging. Results:The scores of FMA-UE, ARAT and WMFT increased after treatment (|t| > 5.298, Z = -3.297, P < 0.01). The FC also increased across the whole brain, including temporal, parietal, occipital lobes and subcortical regions. The FC between left piriform cortex of parietal lobule (BA5L) and right medial surface of temporal lobe (BA48R), as well as those between left precentral gyrus (BA4L) and right anterior transverse temporal gyrus (BA41R) (r > 0.416, P < 0.05). Conclusion:Comprehensive rehabilitation including BCI training may promote recovery of motor function and activities of FC in brain in subacute stroke patients.
