Clinical Characteristics and Risk Factors of Nosocomial Infection in Patients with Spinal Cord Injury
10.3969/j.issn.1006-9771.2019.06.009
- VernacularTitle:脊髓损伤患者医院感染的临床特点及危险因素分析
- Author:
Hui-zhen LIU
1
,
2
;
Guo-wei ZHAO
1
,
2
;
Pei-lan LI
1
,
2
;
Na SHANG
1
,
2
;
Na WANG
1
,
2
;
Lu-shan LIU
1
,
2
Author Information
1. Department of Emergency
2. b. Department of Pharmacy, Beijing Bo’ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
- Publication Type:Research Article
- Keywords:
spinal cord injury;
nosocomial infection;
pathogens;
risk factors
- From:
Chinese Journal of Rehabilitation Theory and Practice
2019;25(6):664-669
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics of nosocomial infection in patients with spinal cord injury, and analyze the risk factors. Methods:From January, 2015 to June, 2017, 526 patients with spinal cord injury in our hospital were reviewed. The distribution of pathogens and the characteristics of drug resistance of strains were summarized, and the risk factors of nosocomial infection were analyzed. Results:There were 159 person-times with nosocomial infection, and most of the infections were found in urinary tract (60.4%) and lower in respiratory tract (28.9%). The main pathogenic germs were Escherichia coli (39.0%), Pseudomonas aeruginosa (15.7%), Klebsiella pneumoniae (11.3%) and Proteus mirabilis (9.4%). The main pathogens were resistant to second or third generation of cephalosporins and quinolones moderately or severely, but sensitive to compound preparations containing beta-lactamase inhibitors, carbapenems and aminoglycosides. The risk factors for the nosocomial infections in the spinal cord injury patients included the hospitalization time, severity of spinal cord injury, invasive operation history, nutritional risk and use of antibiotics (P < 0.05). Conclusion:Most of the nosocomial infections in patients with spinal cord injury are in urinary tract and respiratory tract. Gram-negative bacilli are the main pathogenic bacteria, which often show multiple drug resistance. It is necessary to take targeted interventions according to the risk factors of nosocomial infections in order to improve the quality of life of patients.
