Pulmonary Complications After Hematopoietic Stem Cell Transplantation.
10.3346/jkms.2006.21.3.406
- Author:
Do Hyoung LIM
1
;
Jeeyun LEE
;
Hong Ghi LEE
;
Byeong Bae PARK
;
Kyong Ran PECK
;
Won Sup OH
;
Sang Hoon JI
;
Se Hoon LEE
;
Joon Oh PARK
;
Kihyun KIM
;
Won Seog KIM
;
Chul Won JUNG
;
Young Suk PARK
;
Young Hyuck IM
;
Won Ki KANG
;
Keunchil PARK
Author Information
1. Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Infection;
Hematopoietic Stem Cell Transplantation;
Graft vs. Host Disease
- MeSH:
Transplantation, Homologous;
Transplantation, Autologous;
Transplantation Conditioning;
Middle Aged;
Male;
Lung Diseases/*etiology;
Lung/microbiology;
Humans;
Hematopoietic Stem Cell Transplantation/*adverse effects;
Graft vs Host Disease;
Female;
Bacterial Infections/etiology;
Aged;
Adult;
Adolescent
- From:Journal of Korean Medical Science
2006;21(3):406-411
- CountryRepublic of Korea
- Language:English
-
Abstract:
Despite advanced effective prophylaxes, pulmonary complications still occur in a high proportion of all hematopoietic stem cell recipients, accounting for considerable morbidity and mortality. The aim of our study was to describe the causes, incidences and mortality rates secondary to pulmonary complications and risk factors of such complications following hematopoietic stem cell transplantation (HSCT). We reviewed the medical records of 287 patients who underwent either autologous or allogeneic HSCT for hematologic disorders from February 1996 to October 2003 at Samsung Medical Center (134 autografts, 153 allografts). The timing of pulmonary complications was divided into pre-engraftment, early and late period. The spectrum of pulmonary complications included infectious and non-infectious conditions. 73 of the 287 patients (25.4%) developed pulmonary complications. Among these patients, 40 (54.8%) and 29 (39.7%) had infectious and non-infectious conditions, respectively. The overall mortality rate from pulmonary complications was 28.8%. Allogeneic transplant, grade II-IV acute graft-versus-host disease (GVHD) and extensive chronic GVHD were the risk factors with statistical significance for pulmonary complications after HSCT. The mortality rates from pulmonary complications following HSCT were high, especially those of viral and fungal pneumonia, diffuse alveolar hemorrhage and idiopathic pneumonia syndrome.
