Effects of Repetitive Transcranial Magnetic Stimulation in Different Frequencies on Post-herpetic Neuralgia
10.3969/j.issn.1006-9771.2019.05.015
- VernacularTitle:不同频率高频重复经颅磁刺激治疗带状疱疹后神经痛的效果
- Author:
Qian PEI
1
;
Jia-xiang NI
2
;
Xian-feng GUO
1
;
Qiang HUANG
1
Author Information
1. Department of Rehabilitation Medicine, Beijing Jishuitan Hospital, Beijing 100035, China
2. Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
- Publication Type:Research Article
- Keywords:
post-herpetic neuralgia;
repetitive transcranial magnetic stimulation;
pain;
sleep
- From:
Chinese Journal of Rehabilitation Theory and Practice
2019;25(5):579-585
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in frequencies of 5 Hz and 10 Hz for post-herpetic neuralgia (PHN). Methods:From March, 2017 to March, 2018, 60 PHN patients were randomly divided into groups A (n = 20), B (n = 20) and C (n = 20), who accepted sham rTMS, 5 Hz rTMS and 10 Hz rTMS, respectively, ten times for two weeks. They were assessed with Visual Analogue Scale (VAS) of pain, Pittsburgh Sleep Quality Index (PSQI), Patients' Global Impression of Change Scale (PGIC), medication regulation (MR) and incidence of adverse events, before treatment (T0), immediately after stimulation (T1-T10), one month after treatment (T11) and three months after treatment (T12). Results:Compared with group A, VAS scores reduced in groups B and C at T3-T12 (P < 0.05), and reduced more in group C than in group B at T7-T12 (P < 0.05). The average VAS reduction was less in group B than in group C (χ2 = 5.347, P < 0.05). The PSQI and PGIS scores were less in groups B and C than in group A at T12 (P < 0.05), while it was less in group C than in group B (P < 0.05). There was no significant difference among three groups in MR and the incidence of adverse events. Conclusions:rTMS in either frequencies of 5 Hz or 10 Hz may relieve pain, and improve sleep for PHN patients, while 10 Hz rTMS seems more effective in terms of pain and sleep.
