Detecting Metastatic Bladder Cancer Using 18F-Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography.
- Author:
Hakan OZTURK
1
Author Information
- Publication Type:Original Article
- Keywords: Urinary bladder neoplasms; Neoplasm metastasis; Positron emission tomography; X-ray computed tomography
- MeSH: Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Injections, Intravenous; Male; Neoplasm Metastasis; Positron-Emission Tomography; Retrospective Studies; Sensitivity and Specificity; Skull Base; Thigh; Tomography, X-Ray Computed; Urinary Bladder Neoplasms*; Urinary Bladder*
- From:Cancer Research and Treatment 2015;47(4):834-843
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The purpose of this study was to retrospectively investigate the contribution of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) to detection of metastatic bladder cancer. MATERIALS AND METHODS: The present study included 79 patients (69 men and 10 women) undergoing 18F-FDG-PET/CT upon suspicion of metastatic bladder cancer between July 2007 and April 2013. The mean age was 66.1 years with a standard deviation of 10.7 years (range, 21 to 85 years). Patients were required to fast for 6 hours prior to scanning, and whole-body PET scanning from the skull base to the upper thighs was performed approximately 1 hour after intravenous injection of 555 MBq of 18F-FDG. Whole body CT scanning was performed in the cranio-caudal direction. FDG-PET images were reconstructed using CT data for attenuation correction. Suspicious recurrent or metastatic lesions were confirmed by histopathology or clinical follow-up. RESULTS: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-FDG-PET/CT were 89%, 78%, 90%, 75%, and 86%, respectively. CONCLUSION: 18F-FDG-PET/CT can detect metastases with high sensitivity and positive predictive values in patients with metastatic bladder carcinoma.
