Evaluation of Residual Stepping Ability in Monkeys with Spinal Cord Injury
10.3969/j.issn.1006-9771.2020.06.005
- VernacularTitle:脊髓损伤恒河猴下肢残留跨步能力的评估
- Author:
Can ZHAO
1
;
Rui-han WEI
2
;
Wen ZHAO
3
;
Run JI
4
;
Jia-sheng RAO
1
;
Zhao-yang YANG
3
;
Xiao-guang LI
2
Author Information
1. Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China
2. Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
3. Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069
4. Human Biomechanics Laboratory, National Research Center for Rehabilitation Technical Aids, Beijing 100176, China
- Publication Type:Research Article
- Keywords:
Rhesus monkeys;
spinal cord hemisection;
gait analysis;
residual stepping ability
- From:
Chinese Journal of Rehabilitation Theory and Practice
2020;26(6):648-653
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the residual stepping ability in monkeys with spinal cord injury longitudinally. Methods:Four adult female monkeys were studied. Right hemisection of 10 mm spinal cord tissue was performed at the T7-9 segment. Gait tests of bipedal locomotion were performed before, and six weeks and twelve weeks after injury by VICON system. Gait cycle duration, amplitude of knee and ankle angles, and ratio of united parameters were obtained from successive stepping and were quantitative analyzed. Results:The coordination of bilateral hindlimbs was destroyed after spinal cord injury, and the right hindlimb showed obviously dragging. The gait cycle duration of the left hindlimb increased significantly (P < 0.001), and the amplitudes of knee and ankle angle significantly increased (P < 0.001) after spinal cord injury. The ratio of united parameters was not statistically different among all the time points (P > 0.05). The gait cycle duration of the left hindlimb was correlated with step length (r = 0.838, P = 0.001), step height (r = 0.726, P = 0.007) and amplitude of ankle angle (r = 0.766, P = 0.004), and the amplitude of ankle angle was correlated with step length (r = 0.627, P = 0.029). Conclusion:The gait pattern of monkey with spinal cord injury has been changed. The gait strategy of the uninjured side was adjusted compensatively after spinal cord injury to adapt the functional impairment of contralateral hindlimb.
