Hippocampal Subfield Volumes before and after Treatment for Mild Alzheimer's Disease: Study with Magnetic Resonance Imaging
10.3969/j.issn.1006-9771.2020.05.020
- VernacularTitle:轻度阿尔茨海默病患者治疗前后海马亚区体积的磁共振成像研究
- Author:
Yu LIU
1
;
Zhi-hong CAO
2
;
Yi-feng LUO
2
;
Hai-rong SHAN
2
;
Wen-chao XIE
2
;
Xiao-jie ZHANG
2
;
Wen-yun WANG
2
Author Information
1. Department of Radiology, Yixing Second People's Hospital, Wuxi, Jiangsu 214200, China
2. Department of Neurology, Affiliated Yixing Hospital of Jiangsu University, Wuxi, Jiangsu 214200, China
- Publication Type:Research Article
- Keywords:
Alzheimer's disease;
hippocampus;
magnetic resonance imaging;
diagnosis;
evaluation
- From:
Chinese Journal of Rehabilitation Theory and Practice
2020;26(5):592-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the hippocampal subfield volumes before and after taking hydrochloric donepezil in patients with mild Alzheimer's disease (AD). Methods:From January, 2017 to June, 2018, 25 mild AD patients accepted hydrochloric donepezil (treatment group), 25 patients accepted placebo (placebo group) and 25 age- and gender-matched healthy old people (control group) were scanned with magnetic resonance imaging (MRI) under 3D-T1 TFE sequence before and after a six-month treatment, and the automated segmentation of the hippocampus subfields was fulfilled with FreeSurfer and the hippocampus subfield volumes were compared, while the patients were assessed with Mini-Mental State Examination (MMSE). Results:Compared with the control group, the volumes of left CA1， CA2-3 and CA4-DG, and right CA1 and CA2-3 were reduced in patients before treatment (t > 2.294, P < 0.05). The volume of left CA4-DG increased in the treatment group compared with that of the placebo group after treatment (t = 2.196, P < 0.05), and the volume of bilateral CA1 and CA2-3 tended to increase but not significantly (t < 1.888, P > 0.065). The MMSE score was more in the treatment group than in the placebo group after treatment (t = 2.764, P < 0.05). Conclusion:The association with asymmetric atrophy in the hippocampal subfields has been found in mild AD patients, especially in left CA4-DG, which may be used as a valuable marker for diagnosis and evaluation for treatment at early stage.
