Effects of Electroacupuncture on Brain Function of APP/PS1 Mice: A Functional Magnetic Resonance Imaging Study
- VernacularTitle:电针对APP/PS1小鼠脑功能活动影响的功能性磁共振成像研究
- Author:
Le LI
1
;
Sheng HUANG
1
;
Long LI
1
;
Jia-yong ZHANG
1
;
Ting-ting JIN
1
;
Yu-hao ZHANG
1
;
Bing-xue ZHANG
1
;
Min-guang YANG
1
;
Sheng-xiang LIANG
1
;
Zhi-fu WANG
1
;
Wei-lin LIU
1
;
Jing TAO
1
;
Li-dian CHEN
1
Author Information
- Publication Type:Research Article
- Keywords: Alzheimer's disease; electroacupuncture; learning and memory; brain function; functional magnetic resonance imaging; mice
- From: Chinese Journal of Rehabilitation Theory and Practice 2020;26(5):544-549
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of electroacupuncture at Baihui (DU20) and Shenting (DU24) on brain function of APP/PS1 mice. Methods:Sixteen 4-month-old APP/PS1 mice in the same litter were randomly divided into model group (
n = 8) and electroacupuncture group (n = 8). Eight transgenic negative mice in the same litter were as control group. The electroacupuncture group accepted electroacupuncture at Baihui and Shenting for 16 weeks. They were assessed with Object Recognition Test before and after intervention, and observed under small animal functional magnetic resonance imaging with regional homogeneity (ReHo) analysis. Results:Compared with the control group, the discrimination ratio decreased in the model group after intervention (P < 0.05), while it increased in the electroacupuncture group compared with that in the model group (P < 0.05). Compared with the control group, ReHo of right basal forebrain and left hippocampus decreased in the model group before intervention. Compared with the control group, ReHo decreased in bilateral hippocampus group and increased in retrosplenial cortex in the model group after intervention; while it increased in bilateral hippocampus and motor cortex and decreased in anterior cingulate gyrus in the electroacupuncture group compared with that in the model group. Conclusion:Electroacupuncture at Baihui and Shenting may delay the decline of learning and memory ability in Alzheimer's disease model mice, which may relate to the regulation of functional activities in hippocampus.
