Conventional Cisplatin-Based Combination Chemotherapy Is Effective in the Treatment of Metastatic Spermatocytic Seminoma with Extensive Rhabdomyosarcomatous Transformation.
- Author:
Yumun JEONG
1
;
Jaekyung CHEON
;
Tae Oh KIM
;
Doo Ho LIM
;
Sunpyo LEE
;
Young Mi CHO
;
Jun Hyuk HONG
;
Jae Lyun LEE
Author Information
- Publication Type:Case Report
- Keywords: Seminoma; Drug therapy; Radiotherapy
- MeSH: Biopsy; Cisplatin; Drug Therapy; Drug Therapy, Combination*; Etoposide; Humans; Ifosfamide; Lymph Node Excision; Lymph Nodes; Lymphatic Diseases; Middle Aged; Neck; Orchiectomy; Paclitaxel; Radiotherapy; Rhabdomyosarcoma; Seminoma*
- From:Cancer Research and Treatment 2015;47(4):931-936
- CountryRepublic of Korea
- Language:English
- Abstract: A 52-year-old man was presented with a huge left testicular mass and palpable cervical lymphadenopathy with retroperitoneal lymph node enlargement on an abdominal computed tomography. A left radical orchiectomy and an ultrasound-guided neck node biopsy were performed. A pathological examination revealed spermatocytic seminoma with extensive rhabdomyosarcomatous transformation, a condition known to be highly resistant to platinum-based chemotherapy. The patient received four cycles of etoposide, ifosfamide and cisplatin (VIP) chemotherapy. A repeat computed tomography revealed a substantial regression consistent with a partial response. Retroperitoneal lymph node dissection was attempted, which revealed rhabdomyosarcoma; however, complete microscopic resection was not achieved. After surgery, the residual abdominal lymph node progressed and salvage paclitaxel, ifosfamide and cisplatin (TIP) chemotherapy was employed, which again achieved a partial response. Here, we present a first case report of a spermatocytic seminoma with extensive rhabdomyosarcomatous transformation and multiple metastatic lymphadenopathies that showed a favorable response to platinum-based systemic chemotherapy.
