An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression.
- Author:
Hye Seon KANG
1
;
Hea Yon LEE
;
Seung Joon KIM
;
Seok Chan KIM
;
Young Kyoon KIM
;
Gyeong Sin PARK
;
Kyo Young LEE
;
Jung Im JUNG
;
Ji Young KANG
Author Information
- Publication Type:Case Report
- Keywords: Marginal zone B-cell lymphoma; Lung; Spontaneous neoplasm regression
- MeSH: Ambulatory Care Facilities; Biopsy; Bone Marrow; Cough; Drug Therapy; Dyspnea; Female; Humans; In Situ Hybridization, Fluorescence; Lung; Lymphoid Tissue; Lymphoma; Lymphoma, B-Cell, Marginal Zone*; Middle Aged; Neoplasm Regression, Spontaneous; Thorax
- From:Cancer Research and Treatment 2015;47(4):943-948
- CountryRepublic of Korea
- Language:English
- Abstract: A 57-year-old woman presented with cough and dyspnea for 2 months. Computed tomography of the chest showed diffuse ground-glass opacities in both lungs. Histologic examination via thoracoscopic lung biopsy revealed atypical lymphoproliferative lesion. Her symptoms and radiologic findings of the chest improved just after lung biopsy without any treatment. Therefore, she was discharged and monitored at an outpatient clinic. Two months later, pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma was confirmed by the detection of API2-MALT1 translocation in fluorescent in situ hybridization analysis. Although the lung lesions resolved spontaneously, she received chemotherapy due to bone marrow involvement in her staging workup. Pulmonary MALT lymphoma is rare. Nodular or consolidative patterns are the most frequent radiologic findings. Although the disease has an indolent growth, it rarely resolves without treatment. We report an unusual case of pulmonary MALT lymphoma with diffuse interstitial abnormalities on image and spontaneous regression on clinical course.
