Application of 13N-Ammonia PET/CT Cerebral Blood Perfusion Imaging Combined with Methazolamide Challenge in Ischemic Cerebrovascular Diseases
10.3969/j.issn.1006-9771.2020.07.001
- VernacularTitle:13N-Ammonia PET/CT脑血流灌注显像结合醋甲唑胺负荷试验在缺血性脑血管病中的应用
- Author:
Yu-sheng SU
1
;
Hong-yan WANG
2
;
Xun-ming JI
3
;
Zhi-gang LIANG
1
;
Jie LU
1
;
Chun-lei CUI
1
Author Information
1. Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
2. Department of Nuclear Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
3. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
- Publication Type:Research Article
- Keywords:
ischemic cerebrovascular diseases;
cerebrovascular reserve;
nitrogen radioisotopes;
methazolamide;
positronemission tomography;
computerized tomography;
ischemic preconditioning
- From:
Chinese Journal of Rehabilitation Theory and Practice
2020;26(7):745-748
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To apply 13N-ammonia PET/CT cerebral blood perfusion imaging combined with methazolamide challenge for cerebrovascular reserve (CVR) evaluation in ischemic cerebrovascular diseases. Methods:From January, 2014 to December, 2016, 56 ischemic stroke patients with serious stenosis of unilateral internal carotid artery or middle cerebral artery accepted basal and stress PET/CT with methazolamide challenge. The patients were divided into normal-CVR group (n = 29) and reduced-CVR group (n = 27) according to the results of CVR, and followed up for 24 months. The ischemic cerebrovascular events and cerebral blood flow were observed. Results:The incidence of transient ischemic attack was more in the reduced-CVR group than in the normal-CVR group (χ2 = 4.389, P < 0.05), while the incidence of ischemic stroke increased a little with no significant difference between the two groups (P > 0.05). The CBF was improved in normal-CVR group after treatment (t = 2.409, P < 0.05), and the improvement was not significant in reduced-CVR group (t = 0.648, P > 0.05). Conclusion:13N-ammonia PET/CT cerebral blood flow perfusion imaging combined with methazolamide challenge can be used to evaluate CVR to predict the outcome for patients with cerebral ischemic disease, which is helpful for early intervention.
