Effect of Targeting Mitochondria on Spinal Cord Injury: A Systematic Review Based on Animal Experiments
10.3969/j.issn.1006-9771.2021.05.010
- VernacularTitle:靶向线粒体治疗脊髓损伤的疗效：基于动物实验的系统评价
- Author:
Li-qun WANG
1
;
Ri-zhao PANG
2
;
Jian-cheng LIU
2
;
An-ren ZHANG
3
Author Information
1. School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China
2. Department of Rehabilitation Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, China
3. Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Affiliated to Tongji University School of Medicine, Shanghai 200434, China
- Publication Type:Research Article
- Keywords:
spinal cord injury;
mitochondria;
dysfunction;
treatment;
animal experiment;
systematic review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2021;27(5):574-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the effect of targeting mitochondria on spinal cord injury animal models, and provide experimental evidence. Methods:Literatures about animal experiments of targeting mitochondria treatment for spinal cord injury were searched in PubMed, Web of Science, Web of Knowledge, CNKI and Wanfang database from establishment to February, 2021. Three researchers independently screened the literatures and extracted the data, and they were summarized by qualitative analysis. Results:Eleven animal experimental studies were enrolled, including 548 animals with spinal cord injury. Six studies selected male or female Sprague-Dawley rats, and the rats in eight studies weighed 150~275 g. The animal models of spinal cord injury in all studies focused on T9~T11 contusive spinal cord injury, but there were differences in the use of spinal cord strikers and striking strength. The type, time, frequency, concentration and dosage of intervention drugs were all different. Due to the large heterogeneity of the included studies in animal species, animal models and outcome measures, qualitative analysis was conducted. Conclusion:Targeting mitochondria for spinal cord injury in animals could promote the recovery of motor function, reduce the damaged spinal cord tissue and increase the remaining tissue, enhance the ability of anti-oxidation and anti-apoptosis, and enhance mitochondrial biogenesis. Limited by the number and quality of included studies, the above conclusions need to be verified by more high-quality studies.
