Cancer Chemoprevention by Ginseng in Mouse Liver and Other Organs.
10.3346/jkms.2001.16.S.S66
- Author:
Hoyoku NISHINO
1
;
Harukuni TOKUDA
;
Tsunehiro II
;
Manabu TAKEMURA
;
Masashi KUCHIDE
;
Motohiro KANAZAWA
;
Xiao Yang MOU
;
Ping BU
;
Junko TAKAYASU
;
Mari ONOZUKA
;
Mitsuharu MASUDA
;
Yashiko SATOMI
;
Takao KONOSHIMA
;
Naoki KISHI
;
Masaki BABA
;
Yoshihito OKADA
;
Toru OKUYAMA
Author Information
1. Department of Biochemistry, Kyoto Prefectural University of Medicine, Kyoto, Japan.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Ginseng;
Cancer Chemoprevention;
Suppression of Tumor Promotion;
Liver Neoplasms;
Skin Neoplasms
- MeSH:
Animal;
Anticarcinogenic Agents/*pharmacology;
Female;
Liver Neoplasms, Experimental/*prevention & control;
Male;
Mice;
Mice, Inbred C3H;
*Panax;
Plant Extracts/pharmacology;
Plant Roots;
Skin Neoplasms/*prevention & control
- From:Journal of Korean Medical Science
2001;16(Suppl):S66-S69
- CountryRepublic of Korea
- Language:English
-
Abstract:
Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention.
