Long-term Behavioral Disorder after Hypoxic Ischemic Brain Damage in Newborn Mice
10.3969/j.issn.1006-9771.2021.08.005
- VernacularTitle:新生鼠缺氧缺血性脑损伤远期行为学研究
- Author:
Ai-jin LIN
1
;
Jie-qiong WANG
1
;
Li-juan AO
1
;
Mo-xian CHEN
1
Author Information
1. College of Rehabilitation, Kunming Medical University, Kunming, Yunnan 650500, China
- Publication Type:Research Article
- Keywords:
hypoxic ischemic brain damage;
motor;
recognition;
anxiety;
mice
- From:
Chinese Journal of Rehabilitation Theory and Practice
2021;27(8):908-912
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the long-term behavioral changes in movement, emotion, and learning and memory of newborn mice with hypoxic ischemic brain damage (HIBD). Methods:A total of 50 ten-day old newborn C57BL/6 mice were divided into control group (n = 20) and HIBD group (n = 30). The left common carotid artery was ligated in HIBD group and stayed in anoxic chamber for 45 minutes. All the mice were tested with suspension test, light/dark box test, elevated plus maze test, object recognition test and Y maze test two months after surgery. Results:There were 19 mice modeled successfully. Compared with the control group, the suspension test scores decreased (t = 2.785, P < 0.05); the time of latency of light/dark box test increased (t = -4.320, P < 0.001), the time and frequency in light box decreased (t > 2.603, P < 0.05); the time in open arm decreased (t = 4.576, P < 0.001) and the time in close arm increased (t = -3.287, P < 0.01) for the elevated plus maze test; the time nearing old object increased (t = -2.116, P < 0.05) and object recognition index decreased (t = 2.823, P < 0.05) for object recognition test; the time in the initial and novel arms decreased (t > 2.191, P < 0.05) for Y maze test in HIBD group. Conclusion:The long-term disorders of behavior may include disabilities of motor, learning and memory, and disorder of anxiety, in newborn mice with HIBD.
