Application of Magnetic Resonance Mapping in Progressive Intervertebral Disc Degeneration in Rabbits
10.3969/j.issn.1006-9771.2019.02.008
- VernacularTitle:磁共振Mapping技术诊断兔进展期椎间盘退变
- Author:
Ying-ying HU
1
,
2
;
Jin-wei YING
2
,
3
;
Qi-wen ZHAO
2
,
3
;
Qing-jun WANG
1
,
2
Author Information
1. Department of Radiology
2. c. Department of Pathology, Navy General Hospital, Beijing 100048, China
3. Department of Orthopedics
- Publication Type:Research Article
- Keywords:
intervertebral disc degeneration;
magnetic resonance imaging;
mapping;
rabbits
- From:
Chinese Journal of Rehabilitation Theory and Practice
2019;25(2):172-177
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To apply magnetic resonance T2 mapping and T1 mapping in diagnosing progressive intervertebral disc degeneration. Methods:Seven New Zealand rabbits modeled with intervertebral disc degeneration underwent sagittal T1WI, T2WI, T2 mapping and T1 mapping before, and one and three months after modeling. Pfirrmann grade of six intervertebral discs (L1-S1) in each rabbit was obtained based on T2WI and values of T2 and T1 based on T2 mapping and T1 mapping. They were observed pathologically as progressive or non-progressive intervertebral disc degeneration. The diagnostic efficacy of these imaging markers was compared with receiver operating characteristic (ROC) curve according to pathological results. Results:T2 values of intervertebral discs decreased after degeneration (F = 24.224, P < 0.001), while T1 values varied little (F = 2.191, P = 0.116). The diagnostic efficacy from more to less ranked as T2 mapping+T1 mapping = T2 mapping > T1 mapping > Pfirrmann grade. Conclusion:T2 mapping may differentiate progressive intervertebral disc degeneration from non-progressive for clinic.
