Investigation on Correlation of Phase Behavior and Stability of Curcumin Self-nanoemulsion with Different Drug Loading After in Vitro Dispersion
10.13422/j.cnki.syfjx.20201949
- VernacularTitle:不同载药量姜黄素自纳米乳体外分散后相行为与稳定性的相关性考察
- Author:
Xu-long CHEN
1
;
Xin-li LIANG
1
;
Huan LIU
1
;
Guo-wei ZHAO
1
;
Jia-hao WEN
1
;
Liao-qi OUYANG
1
;
Qie-ying JIANG
1
;
Zheng-gen LIAO
1
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine （TCM）， Ministry of Education，Experimental Animal Science and Technology Center， Jiangxi University of TCM，Nanchang 330004，China
- Publication Type:Research Article
- Keywords:
curcumin;
self-nanoemulsion;
drug loading;
artificial gastrointestinal fluid;
phase behavior;
supersaturation;
crystal
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(1):154-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between phase behavior of curcumin （CUR） from self-nanoemulsion drug delivery system （SNEDDS） and stability of the formed nanoemulsion in artificial gastrointestinal fluid. Method:The growth rate of precipitation after dispersion of CUR-SNEDDS was expressed by the change tendency of CUR supersaturation-time curve. The effect of drug loading on crystal nucleation and growth was investigated by ultraviolet-visible spectrometry and polarized light microscope， respectively. X-ray powder diffraction （XRD） and differential scanning calorimetry （DSC） were used to analyze the precipitation forms of CUR-SNEDDS with different drug loading in artificial gastrointestinal fluid. At the same time， the effect of drug loading on the quality stability of nanoemulsion formed by CUR-SNEDDS in artificial gastrointestinal fluid was investigated. Result:In the artificial gastrointestinal fluid， with the increase of drug loading， the area under the supersaturation-time curve of CUR was increased （100% drug loading≈90% drug loading>75% drug loading）， the crystallization nucleation and growth rate were accelerated （100% drug loading>90% drug loading>75% drug loading）， the amorphous proportion in the precipitation composition decreased， the nanoemulsion droplets adhered and distributed unevenly， the particle size and dispersivity were increased. Conclusion:High drug loading promotes the nucleation and growth of crystals， and increases the proportion of crystal forms in the precipitation composition， which leads to the decrease in the stability of the formed nanoemulsion. Therefore， it is suggested that the drug loading of CUR-SNEDDS needs to be controlled below 90%.
