Feasibility Analysis and Study Progress of Effect of Huangjingwan in Prevention and Treatment of Alzheimer's Disease
10.13422/j.cnki.syfjx.20202105
- VernacularTitle:黄精丸防治阿尔茨海默病的可行性探析及研究进展
- Author:
Jing-ying YANG
1
;
Yi-sheng XIAO
1
;
Ai-jiao XIAO
1
;
Hao-zhong XIONG
1
;
Jie-lin JIANG
1
;
Hou-gan OUYANG
1
Author Information
1. College of Traditional Chinese Medicine（TCM），Jiangxi University of TCM， Nanchang 330004， China
- Publication Type:Research Article
- Keywords:
Huangjingwan;
Polygonati Rhizoma;
Angelicae Sinensis Radix;
Alzheimer's disease;
theoretical analysis;
research overview
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(1):46-52
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease （AD） is a neurodegenerative disease that leads to progressive memory and cognitive impairment and behavioral disorders， which has seriously threatened the health of the majority of middle-aged and elderly people. Traditional Chinese medicine （TCM） believes that the basic pathogenesis of AD is deficiency of kidney-essence， blood stasis and meridian stagnation. In recent years， many studies have shown that TCM has obvious value and advantages in the prevention and treatment of AD by multi-target mechanism. Therefore， it is of great significance to screen out effective anti-AD drugs from TCM compound prescriptions. Huangjingwan， also known as Jiuzhuan Huangjingwan， has the effects in tonifying kidney-essence， activating blood and removing stasis， with a potential effect in preventing AD. In this article， the feasibility of Huangjingwan in the prevention and treatment of AD was analyzed and discussed from the perspective of TCM theory， the study results of Huangjingwan in the prevention and treatment of AD were summarized， and the mechanism of its action was analyzed from the perspective of pharmacological mechanism. Based on TCM theory， Huangjingwan has the effect of anti-AD. According to relevant findings， Huangjingwan has many targets， such as anti-oxidation， anti-inflammatory， decrease of the level of oxidative stress in brain， activation of Wnt/β-catenin signal transduction in brain， regulation of glycogen synthase kinase-3β （GSK-3β）， protein phosphatase 2A （PP2A） activity balance， reduction of amyloid β （Aβ） content and tau protein hyperphosphorylation in brain， so as to exert effects in improving neurological symptoms and increasing learning and memory ability， with an anti-AD neuroprotective function. This will provide new ideas for in-depth studies and clinical applications of Huangjingwan against AD.
