Research progress of insulin resistance and hyperinsulinemia promoting pancreatic cancer

Author: LI Shanshan ; ZHAO Yulan
Publication Type:Journal Article
Keywords: pancreatic cancer；insulin resistance；hyperinsulinemia；type 2 diabetes mellitus
From: Journal of Preventive Medicine 2021;33(11):1122-1126
CountryChina
Language:Chinese
Abstract: Pancreatic cancer is a common digestive tract carcinoma. It is strongly occult and lack of early diagnostic indicators, and the patients have quite low survival rates. The pathogenesis of pancreatic cancer remains unclear. It has been reported that smoking, family history, diabetes mellitus and obesity are associated with the incidence of pancreatic cancer; moreover, type 2 diabetes mellitus (T2DM) often occur as a comorbidity. Insulin resistance and compensatory hyperinsulinemia are the main metabolic characteristics of T2DM, which play an important role in the development and progression of pancreatic cancer. The molecular mechanisms of insulin resistance and hyperinsulinemia promoting pancreatic cancer are reviewed in this paper, in order to provide the evidence for the prevention and treatment of pancreatic cancer.
Full text:胰岛素抵抗及高胰岛素血症促进胰腺癌发生的研究进展.pdf