Advances in the toxicokinetic models of cadmium
10.19485/j.cnki.issn2096-5087.2021.11.008
- Author:
QING Ying
;
WANG Liqiang
- Publication Type:Journal Article
- Keywords:
cadmium；toxicokinetic model；physiologically-based toxicokinetic model
- From:
Journal of Preventive Medicine
2021;33(11):1113-1117
- CountryChina
- Language:Chinese
-
Abstract:
Cadmium is a toxic heavy metal commonly seen in the environment. Long-term exposure to low dose of cadmium has toxic effects on multiple systems and organs of human body. The kinetic model is a new technology to quantitatively evaluate the correlation between internal and external exposure of chemicals, which can provide reliable information for risk assessment. There are two kinetic models of cadmium: toxicokinetic model (TK) and physiologically-based toxicokinetic model (PBTK). They have played a role in the establishment of cadmium exposure limits and risk prediction. This article reviews the construction, development, and limitations of the two models, and looks forward to the direction in which the models can be further optimized, providing the reference for risk assessment of cadmium exposure in China.
- Full text:重金属镉的毒代谢动力学模型研究进展.pdf
