Research advances in the association between liver failure and intestinal barrier injury
10.3969/j.issn.1001-5256.2021.11.049
- VernacularTitle:肝衰竭与肠道屏障损害关系的研究进展
- Author:
Lingyan XIAO
1
;
Awen XING
2
;
Shanzhong TAN
3
Author Information
1. Department of Critical Care Medicine, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210003, China
2. School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
3. Department of Integrated Traditional Chinese and Western Medicine for Liver Diseases, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210003, China
- Publication Type:Reviews
- Keywords:
Liver Failure;
Intestinal Mucosal Barrier;
Gastrointestinal Microbiome;
Therapeutics
- From:
Journal of Clinical Hepatology
2021;37(11):2710-2714
- CountryChina
- Language:Chinese
-
Abstract:
Liver failure and intestinal barrier injury, especially intestinal microflora imbalance, interacts as both the cause and effect of each other. Intestinal barrier injury is observed during liver failure, including the injuries of chemical, mechanical, immune, and microbial barriers, and meanwhile, gut dysbiosis, increased bacterial endotoxins, and abnormal bile acid metabolism may affect hepatocyte regeneration, increase complications, and aggravate the conditions of liver failure. The maintenance of intestinal barrier function should be taken seriously in the treatment of liver failure, and the treatment targeting intestinal barrier injury, especially microecological disturbance, is a promising method.
