Role of erythropoietin-producing hepatocyte receptors in the pathogenesis of liver fibrosis and hepatocellular carcinoma

VernacularTitle:促红细胞生成素产生肝细胞受体在肝纤维化、肝癌发病机制中的作用
Author: Weizhao TONG ^{1
,

2} ; Wei LIU ^{3
,

4} ; Guoxin HU ¹
Author Information

1. Department of Infectious Diseases, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China
2. Shantou University Medical College, Shantou, Guangdong 515041, China
3. Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center
4. Shenzhen Key Laboratory for Neuronal Structural Biology, Shenzhen 518036, China
Publication Type:Reviews
Keywords: Erythropoietin Producing Hepatocyte Receptor; Liver Cirrhosis; Carcinoma, Hepatocellular
From: Journal of Clinical Hepatology 2021;37(11):2663-2666
CountryChina
Language:Chinese
Abstract: Erythropoietin-producing hepatocyte (Eph) receptors are the largest subgroup of the receptor tyrosine kinase family and are involved in the physiological processes such as embryonic development, angiogenesis, and axon guidance. Recent studies have shown that Eph receptors are overexpressed in liver fibrosis and hepatocellular carcinoma tissues and play an important role in the growth, invasion, and metastasis of hepatocellular carcinoma. This article explores the mechanism of action of Eph receptors in liver fibrosis and hepatocellular carcinoma and points out that Eph receptors may be important molecules in the development and progression of liver fibrosis and hepatocellular carcinoma.