Clinical features of drug-induced liver failure and related diagnosis and treatment strategies
10.3969/j.issn.1001-5256.2021.11.006
- VernacularTitle:药物性肝衰竭的临床特点及诊治策略
- Author:
Rongtao LAI
1
;
Qing XIE
1
Author Information
1. Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
- Publication Type:Discussions by experts
- Keywords:
Chemical and Drug-Induced Liver Injury;
Liver Failure;
Diagnosis;
Therapeutics
- From:
Journal of Clinical Hepatology
2021;37(11):2534-2538
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of drug-induced liver injury (DILI) has risen considerably in recent years. Drug-induced liver failure tends to have severe conditions, limited therapeutic strategy, and a high mortality rate and should thus be taken seriously by clinicians. N-acetyl-p-aminophenol is the most common cause of acute liver failure (ALF) in Western countries; for ALF associated with idiosyncratic DILI (iDILI), since there is little in-deep understanding of host susceptibility and pathogenesis, it is difficult to identify ALF caused by iDILI in the early stage, and due to a low rate of spontaneous recovery and poor prognosis, it has become a major indication for emergency liver transplantation in many countries. A comprehensive understanding of the clinical features and prognostic prediction of drug-induced liver failure and the search for new reliable diagnostic methods and effective treatment strategies are of vital importance in reducing the disease burden of drug-induced liver failure.
