Role of exosomes in the development and progression of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2021.10.047
- VernacularTitle:外泌体在非酒精性脂肪性肝病发生发展中的作用
- Author:
Kun XU
1
;
Qinglan SHI
2
;
Zhenbin HU
2
;
Xu ZHANG
1
;
Ying LI
1
Author Information
1. Graduate School of Guangxi University of Chinese Medicine, Nanning 530222, China
2. First Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
- Publication Type:Reviews
- Keywords:
Exosomes;
Non-Alcoholic Fatty Liver Disease;
Liver Diseases
- From:
Journal of Clinical Hepatology
2021;37(10):2478-2481
- CountryChina
- Language:Chinese
-
Abstract:
With the increasing incidence rates of metabolic diseases such as obesity and type 2 diabetes, the incidence rate of nonalcoholic fatty liver disease (NAFLD) has also gradually increased year by year. NAFLD has complex underlying pathogeneses which have not yet been fully clarified. As the carrier of intercellular communication, exosomes play an important role in the development and progression of liver diseases. This article summarizes the mechanism of action of exosomes in the pathogenesis of NAFLD and their effect on lipid metabolism, insulin resistance, liver inflammation, and fibrosis, and it is pointed out that exosomes have great potential in the diagnosis and treatment of diseases, which will be the focus of future research.
