Influence of circadian rhythm disorder on nonalcoholic fatty liver disease and related hepatocellular carcinoma
10.3969/j.issn.1001-5256.2021.10.045
- VernacularTitle:昼夜节律紊乱对非酒精性脂肪性肝病及相关肝细胞癌的影响
- Author:
Jinxia ZHU
1
;
Guangwei LIU
2
;
Peiwei YANG
2
Author Information
1. The First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
2. Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Reviews
- Keywords:
Non-Alcoholic Fatty Liver Disease;
Carcinoma, Hepatocellular;
Circadian Rhythm;
Circadian Rhythm Signaling Peptides and Proteins;
Gastrointestinal Microbiome
- From:
Journal of Clinical Hepatology
2021;37(10):2469-2473
- CountryChina
- Language:Chinese
-
Abstract:
The influence of circadian rhythm disorder on nonalcoholic fatty liver disease (NAFLD) has attracted more and more attention in recent years, and studies in China and globally have shown that individuals who work in shifts at night or often stay up late have a higher incidence rate of NAFLD-related hepatocellular carcinoma (NAFLD-HCC) than those with regular work and rest. This article summarizes the research advances in the effect of circadian rhythm system on the pathogenesis of NAFLD-HCC by regulating lipid metabolism, glucose metabolism, and intestinal flora, and it is pointed out that restoration of normal circadian rhythm has potential clinical significance in delaying the development and progression of disease.
