Mechanism of KLF4 in the development and progression of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2021.10.041
- VernacularTitle:Krüppel样因子4在肝细胞癌发生发展中的作用机制
- Author:
Fei SUN
1
;
Weiwei SU
1
;
Yanhua FU
1
;
Jingwei WANG
1
Author Information
1. Department of Hepatology, Qilu Hospital(Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong 266035, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Hepatocellular;
Kruppel-Like Transcription Factors;
Biological Function;
Molecular Mechanism
- From:
Journal of Clinical Hepatology
2021;37(10):2452-2455
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of hepatocellular carcinoma is complex and has not been fully clarified. KLF4, also known as gut-enriched Kruppel-like factor (GKLF), plays the dual regulatory role of tumor suppressor and tumor promoter. KLF4 plays an anti-cancer role in liver cancer. This article introduces the biological function and regulatory mechanism of KLF4 in the progression of liver cancer, and research on the mechanism of action of KLF4 in liver cancer is expected to provide new ideas for targeted therapy and prognosis monitoring of liver cancer.
