Research advances in Kupffer cells participating in the regulation of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2021.10.040
- VernacularTitle:Kupffer细胞在肝细胞癌中的调控机制
- Author:
Pingfu XIONG
1
;
Hao CHEN
1
;
Wenguang FU
1
;
Peng TAN
2
;
Yonglang CHENG
1
;
Jing LI
1
Author Information
1. Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
2. Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Hepatocellular;
Kupffer Cells;
Cytokines
- From:
Journal of Clinical Hepatology
2021;37(10):2448-2451
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is a common type of primary liver cancer with high mortality worldwide. Among the common malignant tumors in China, HCC ranks fourth in terms of incidence rate and ranks second in terms of mortality, which seriously threatens the health and life safety of the Chinese people. This article mainly introduces the dual role of Kupffer cells (KCs) in HCC and briefly describes its interaction with liver parenchymal cells and nonparenchymal cells and related targeted treatment methods. The analysis shows that in-depth research on KCs in the regulation of HCC helps to provide new ideas for further treatment of HCC.
