Role and mechanism of exosome non-coding RNA in liver fibrosis
10.3969/j.issn.1001-5256.2021.10.036
- VernacularTitle:外泌体非编码RNA在肝纤维化中的作用及机制
- Author:
Nannan QIAN
1
;
Lulu TANG
2
;
Taohua WEI
1
,
2
;
Yue YANG
1
;
Wenjie HAO
1
;
Wenming YANG
2
,
3
Author Information
1. Graduate School, Anhui University of Chinese Medicine, Hefei 230038, China
2. Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China
3. Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei 230038, China
- Publication Type:Reviews
- Keywords:
Liver Cirrhosis;
Exosomes;
RNA, Untranslated
- From:
Journal of Clinical Hepatology
2021;37(10):2429-2434
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is the initial stage of the development of various chronic liver diseases into liver cirrhosis and is a reversible process. As a subset of extracellular vesicles that can carry active substances such as proteins, lipids, and RNA, exosomes are involved in intercellular signal communication and have attracted more and more attention in recent years. Studies have shown that non-coding RNAs in exosomes play an important role in the development and progression of liver fibrosis. This article discusses the mechanism of action of exosome long non- coding RNAs (including MALAT1, H19, GAS5, MEG3, PVT1, and P21), exosome short non-coding RNAs (including micro-RNA, small nucleolus RNA, PIWI-interacting RNA, and small interference RNA), and exosome circular RNA in the development and progression of liver fibrosis, and it is concluded that exosomes from different sources (such as hepatocytes and cholangiocytes) carrying non-coding RNAs mainly affect the activation, proliferation, migration, and transformation of hepatic stellate cells. In-depth studies of exosome non-coding RNAs in the future are expected to find potential new targets for the treatment of liver fibrosis.
