Mechanism of estrogen against liver fibrosis in postmenopausal women with chronic liver disease
10.3969/j.issn.1001-5256.2021.10.035
- VernacularTitle:慢性肝病女性患者绝经后雌激素抗肝纤维化的作用机制
- Author:
Wenqian XU
1
;
Yaoqi WU
1
;
Jinyuan ZHANG
1
;
Tianchuang YANG
1
;
Heguo LI
2
;
Min GUO
2
Author Information
1. The First Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
2. Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Reviews
- Keywords:
Liver Cirrhosis;
Estrogens;
Menopause;
Femininity
- From:
Journal of Clinical Hepatology
2021;37(10):2425-2428
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic disorders are observed in women after menopause, and the postmenopausal women suffering from chronic liver diseases have an increased risk of progression to liver fibrosis, with a higher risk than male patients of the same age, which may be associated with the decline of ovarian function and the reduction of estrogen level after menopause. This article summarizes the research advances in the molecular mechanism of progression to liver fibrosis from the aspects of estrogen and oxidative stress, activation of hepatic stellate cells, accumulation of extracellular matrix, and immune regulation. It is pointed out supplementation with an appropriate amount of estrogen in the perimenopausal period and the early menopausal period can reduce the risk of liver fibrosis and delay or even reverse the process of liver fibrosis, thereby improving quality of life and prolonging survival time in elderly female patients.
