Mechanism of action of Fuzheng Huayu prescription in treatment of liver cancer based on network pharmacology
10.3969/j.issn.1001-5256.2021.10.016
- VernacularTitle:基于网络药理学探讨扶正化瘀方治疗肝癌的作用机制
- Author:
Jingshu QI
1
;
Dabing PING
1
;
Xin SUN
2
;
Jingbo XUE
1
;
Yanyan TAO
1
;
Yuan PENG
1
;
Chenghai LIU
1
,
2
,
3
,
4
Author Information
1. Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2. Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, China
3. Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai 201203, China
4. Shanghai Innovation Center of TCM Health Service, Shanghai 201203, China
- Publication Type:Original articles_Liver neoplasms
- Keywords:
Liver Neoplasms;
Fuzheng Huayu Decoction;
Network Pharmacology
- From:
Journal of Clinical Hepatology
2021;37(10):2338-2342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of Fuzheng Huayu(FZHY) decoction in the treatment of liver cancer based on network pharmacology. Methods TCMSP, BATMAN, and Drugbank databases were searched for the main chemical components and corresponding targets of FZHY, and STRING database was used to perform a PPI network analysis. Cytoscape software was used to establish a drug-disease network model and perform a network analysis, and R language was used to perform GO and KEGG enrichment analysis of targets. Results A total of 192 intersection genes between FZHY and liver cancer and 95 potential compounds were screened out, among which quercetin and luteolin were the active components with an important regulatory role. INS, IL-6, and EGFR were the key targets for the potential effect of FZHY. The GO enrichment analysis showed the involvement in various biological processes such as response to drug and response to oxygen level, and the KEGG enrichment analysis showed the involvement in the signaling pathways including apoptosis and tumor necrosis factor signaling pathways. Conclusion Based on the method of network pharmacology, this study reveals the mechanism of action of multiple targets and targets of FZHY in the treatment of liver cancer, which provides a theoretical basis for clinical and basic scientific research.
