Research advances in animal models of primary biliary cholangitis
10.3969/j.issn.1001-5256.2021.10.006
- VernacularTitle:原发性胆汁性胆管炎动物模型的研究进展
- Author:
Yafei XU
1
;
Zhibin ZHAO
2
;
Zhexiong LIAN
1
Author Information
1. School of Medicine, South China University of Technology, Guangzhou 510006, China
2. Guangdong Provincial People's Hospital, Guangzhou 510000, China
- Publication Type:Discussions by experts
- Keywords:
Autoimmune Diseases;
Liver Cirrhosis, Biliary;
Disease Models, Animal
- From:
Journal of Clinical Hepatology
2021;37(10):2280-2285
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis (PBC) is an inflammatory and cholestatic liver disease caused by autoimmune response targeting the small- and medium-sized intrahepatic bile ducts. The most specific manifestations of this diseases in clinical practice were positive anti-mitochondrial antibody and selective destruction of small- and medium-sized bile ducts based on liver histology. Since it is difficult to obtain the clinical samples of early-stage PBC, the construction and optimization of mouse models is an important method to investigate the pathogenesis of PBC. An understanding of the modeling principles of PBC animal models and disease features in serology, histology, and cytology not only helps to improve the awareness of PBC, but also helps to design scientific and rational research protocols.
