New advances in the treatment of pancreatic cancer by targeting tumor microenvironment
10.3969/j.issn.1001-5256.2021.09.049
- VernacularTitle:靶向肿瘤微环境治疗胰腺癌的新进展
- Author:
Feiyu ZHANG
1
;
Yakepu ADILA
1
;
Jinming ZHAO
1
;
Yanhang GAO
1
Author Information
1. Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Reviews
- Keywords:
Pancreatic Neoplasms;
Tumor Microenvironment;
Immunotherapy
- From:
Journal of Clinical Hepatology
2021;37(9):2246-2248
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is the malignant tumor of the digestive tract with the lowest 5-year survival rate, and current first-line treatment regimens cannot significantly improve the overall prognosis of patients, so it is necessary to explore new treatment methods. A large number of studies have shown that the tumor microenvironment of pancreatic cancer, such as stromal barrier, immune microenvironment, and exosomes, plays an important role in promoting the proliferation, invasion, metastasis, and chemoradiotherapy resistance of pancreatic cancer cells. This article summarizes the potential targets associated with the tumor microenvironment of pancreatic cancer and related clinical research advances, in order to provide new ideas for the treatment of pancreatic cancer.
