Role of miRNA in the development and progression of cholangiocarcinoma
10.3969/j.issn.1001-5256.2021.09.048
- VernacularTitle:微小RNA在胆管癌发生发展中的作用
- Author:
Sheng CHEN
1
;
Guoxiang CHEN
1
;
Zhongming HE
2
;
Shujie CHENG
1
;
Jisen ZHAO
1
Author Information
1. Department of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China
2. School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646000, China
- Publication Type:Reviews
- Keywords:
Bile Duct Neoplasms;
MicroRNAs;
Exosomes;
Therapeutics
- From:
Journal of Clinical Hepatology
2021;37(9):2241-2245
- CountryChina
- Language:Chinese
-
Abstract:
Cholangiocarcinoma is the most common malignant tumor of the biliary tract, with a relatively high mortality rate and an incidence rate increasing year by year. Due to atypical symptoms in the early stage and complex anatomical location, it is often difficult for patients with cholangiocarcinoma to be diagnosed in the early stage, and therefore, they often miss the optimal treatment period and tend to have poor prognosis. In recent years, studies have shown that miRNAs play a key role in the pathophysiological process of the development and progression of cholangiocarcinoma. This article reviews the regulatory role of miRNAs in the development, invasion, metastasis, drug resistance, and tumor microenvironment of cholangiocarcinoma and introduces the latest advances in exosome miRNA and cholangiocarcinoma, so as to provide potential treatment strategies for cholangiocarcinoma.
