Research advances in the association between activating transcription factor 3 and chronic liver diseases

VernacularTitle:转录激活因子3与慢性肝脏疾病相关性的研究进展
Author: Qunli GU ^{1
,

2} ; Hui LI ¹ ; Xiuxiu DENG ^{1
,

2} ; Zijian ZENG ^{1
,

2} ; Haijian DONG ^{1
,

2}
Author Information

1. Central Laboratory, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
2. School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
Publication Type:Reviews
Keywords: Activating Transcription Factor 3; Non-alcoholic Fatty Liver Disease; Liver Cirrhosis; Liver Neoplasms
From: Journal of Clinical Hepatology 2021;37(9):2236-2240
CountryChina
Language:Chinese
Abstract: Activating transcription factor 3 (ATF3) belongs to the transcription factor ATF/CREB family and is a stress-induced adaptive response gene. ATF3 is involved in the regulation of various cell activities to adapt to the changes in intracellular and extracellular environments. Recent studies have shown that ATF3 plays an important role in the development and progression of various chronic liver diseases, including nonalcoholic fatty liver disease, liver fibrosis, and liver cancer, by regulating gluconeogenesis, lipid metabolism, and immune function. This article reviews the mechanism of action of ATF3 in chronic liver diseases.