Association of circadian rhythm and related genes with nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2021.09.045
- VernacularTitle:昼夜节律及其相关基因与非酒精性脂肪性肝病的关系
- Author:
Chenlu ZHAO
1
;
Wenxia ZHAO
2
Author Information
1. The First Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou 450016, China
2. Department of Hepatology and Splee-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Reviews
- Keywords:
Circadian Rhythm;
Gene;
Non-alcoholic Fatty Liver Disease
- From:
Journal of Clinical Hepatology
2021;37(9):2225-2230
- CountryChina
- Language:Chinese
-
Abstract:
The association between circadian rhythm and metabolic diseases has attracted more and more attention in recent years. A large number of clinical studies have shown that people who often stay up late or work in shifts have a significantly higher risk of nonalcoholic fatty liver disease than those with regular work and rest. Based on current research findings, this article reviews the mechanism of action of circadian rhythm genes in nonalcoholic fatty liver disease from the five aspects of lipid metabolism, glucose metabolism, intestinal flora, oxidative stress, and endoplasmic reticulum stress.
