Role of N6-methyladenosine in the development and progression of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2021.09.042
- VernacularTitle:N6-甲基腺苷在肝细胞癌发生发展中的作用
- Author:
Ke MA
1
;
Lijin ZHAO
1
Author Information
1. Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Hepatocellular;
N6-Methyladenosine;
Methyltransferases;
Demethylase;
m6A Binding Proteins
- From:
Journal of Clinical Hepatology
2021;37(9):2210-2214
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has relatively high incidence and mortality rates. Abnormal modification of N6-methyladenosine (m6A) may promote the development and progression of HCC. This article describes the structure and function of m6A and summarizes the mechanism of action of methylase complexes which decide the function of m6A in HCC, including methyltransferases (writers), demethylases (erasers), and m6A-binding proteins (readers). It is pointed out that more in-depth studies are needed to clarify the diverse and specific role of methylase complexes in HCC, so as to help them become the new targets for the prevention and treatment of HCC in the future.
