Phylogenomic analysis of SARS-CoV-2 from third wave clusters in Malaysia reveals dominant local lineage B.1.524 and persistent spike mutation A701V
https://doi.org/10.47665/tb.38.3.070
- Author:
Suppiah, J.
1
;
Kamel, K.A.
1
;
Mohd-Zawawi, Z.
1
;
Afizan, M.A.
1
;
Yahya, H.
2
;
Md-Hanif, S.A.
3
;
Thayan, R.
1
Author Information
1. Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Selangor, Malaysia
2. Disaster, Outbreak, Crisis and Emergency Management Sector, Surveillance Section, Disease Control Division, Ministry of Health Malaysia, Federal Government Administrative Centre, Putrajaya, Malaysia
3. International Travel and Health Regulation Sector, Surveillance Section, Disease Control Division, Ministry of Health Malaysia, Federal Government Administrative Centre, Putrajaya, Malaysia
- Publication Type:Other Types
- Keywords:
COVID-19;
phylogenomic;
Malaysia;
A701V;
third wave
- From:Tropical Biomedicine
2021;38(No.3):289-293
- CountryMalaysia
- Language:English
-
Abstract:
The emergence of a third wave of COVID-19 infection in Malaysia since September 2020 has led to imminent changes in public health prevention and control measures. As high as 96.2% of registered COVID-19 cases and 88.5% of confirmed deaths in Malaysia occurred during this third wave of infection. A phylogenomic study on 258 SARS-CoV-2 full genomes from February 2020-February 2021 has led to the discovery of a novel Malaysian lineage B.1.524. This lineage contains another spike mutation A701V that co-exists with the D614G spike mutation that was predominant in most of the third-wave clusters. The study provides vital genomic insights on the rapid spread of the SARS-CoV-2 variants in Malaysia in conjunction with the presence of a dominant SARS-CoV-2 lineage during the third wave of COVID-19 infection.
- Full text:8.2021my1269.pdf
