Analysis of clinical pharmacists participating in the treatment of a case of sodium valproate poisoning
10.12206/j.issn.1006-0111.202103017
- VernacularTitle:临床药师参与一例丙戊酸钠中毒患者救治过程分析
- Author:
Jingming ZHANG
1
;
Wenjie LU
1
;
Shuqin ZHOU
2
;
Jian ZHAO
2
;
Honghong WAN
2
;
Yugang ZHUANG
2
Author Information
1. Department of Pharmacy.
2. Department of Emergency, the Tenth People’s Hospital Affiliated to Tongji University, Shanghai 200072, China.
- Keywords:
sodium valproate;
poisoning;
blood drug concentration monitoring;
blood purification;
hemoperfusion;
clinical pharmacists.
- From:
Journal of Pharmaceutical Practice
2021;39(6):566-568
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of clinical pharmacists in the treatment of drug poisoning by analyzing the clinical pharmacist's participation in the treatment of a patient with sodium valproate poisoning. Methods Clinical pharmacists measured the plasma concentration of sodium valproate to inform the doctor to diagnose illnesses. At the initial stage when the concentration is high, to eliminate the free drug by continuous venous-venous hemodialysis-filtration (CVVHDF). Then, the combined drug was cleared by hemoperfusion (HP). Results The blood concentration dropped by half at the first CVVHDF and decreased obviously after two HPs. After stable observation in five days’ course of disease, the blood concentration was maintained at a low level and the patient was cured and discharged. Conclusion The implementation of the blood purification program under the monitoring of the blood drug concentration with the participation of pharmacists is helpful for the rescue of drug overdose and is worthy of promotion.
