Effect of compound bone peptide injection on osteoporotic fractures of thoracolumbar spine, bone density and bone metabolism
10.12206/j.issn.1006-0111.202101002
- VernacularTitle:复方骨肽注射液应用于胸腰椎骨质疏松性骨折患者中的效果及对患者骨密度与骨代谢的影响
- Author:
Fei PEI
1
;
Haifeng WANG
1
Author Information
1. Section Ⅱ, Department of Orthopaedics, Marine Police General Corps Hospital of the Chinese People's Armed Police Force, Jiaxing 314000, China.
- Keywords:
compound bone peptide injection;
bone metabolism;
bone mineral density;
osteoporosis of thoracolumbar spine
- From:
Journal of Pharmaceutical Practice
2021;39(6):557-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of compound bone peptide injection in patients with thoracolumbar osteoporotic fracture. Methods 96 patients admitted from January 2018 to January 2020 with thoracolumbar osteoporotic fracture were selected. The patients were randomly divided into group A (receiving calcine D with compound bone peptide injection) and group B (receiving calcine D treatment) with 48 patients in each group. TCM symptom scores, bone metabolism, degree of osteoporosis, bone density level, visual analogue scale (VAS) and lumbar spine disease treatment score (JOA) were compared between the two groups after treatment. Results After treatment, the TCM symptom score and JOA score in group A were higher than those in group B (P<0.05). The levels of bone alkaline phosphatase (BALP) and type I procollagen N-terminal propeptide (PIINP) in group A were significantly lower than those in group B (P<0.05). The grade 3 osteoporosis ratio in group A was lower than that in group B (P<0.05). The bone mineral density level in group A was higher than that in group B (P<0.05). The visual analogue scale (VAS) in group A was lower than that in group B (P<0.05). Conclusion The treatment of thoracolumbar osteoporotic fracture with compound bone peptide injection effectively improved the bone metabolism and bone mineral density, relieved pain and promoted the recovery of lumbar function.
