Treatment and pharmaceutical care of one patient with Chlamydia psittaci pneumonia complicated by drug-induced liver injury
10.12206/j.issn.1006-0111.202103043
- VernacularTitle:1例鹦鹉热衣原体重症肺炎并发药物性肝损伤患者的治疗及药学监护
- Author:
Yunying HU
1
;
Jin FENG
1
;
Yao JIA
1
;
Jiyun GE
1
;
Leilei BAO
1
;
Yufeng HUANG
1
Author Information
1. .
- Keywords:
Chlamydia psittaci;
severe pneumonia;
antimicrobial agents;
drug-induced liver injury;
pharmaceutical care
- From:
Journal of Pharmaceutical Practice
2021;39(6):552-556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of clinical pharmacists in rational drug use through the pharmacy care of an elderly pneumonia patient with Chlamydia psittaci infection and drug-induced liver injury. Methods The clinical pharmacists participated in the treatment of one patient with Chlamydia psittaci pneumonia and drug-induced liver injury. Based on the results of second-generation gene sequencing, the characteristics of the pathogen were learned by literature search. The clinical pharmacists monitored the patient’s liver and kidney function, provided a new medication treatment plan to Doctors, and performed patient education during the treatment. Results The initial empirical anti-infective treatment with teicoplanin and imipenem-cilastatin was not effective. After the diagnosis of Chlamydia psittaci and Candida albicans infection, the combination of doxycycline with azithromycin and fluconazole was administered. Drug-induced liver injury was found with this treatment. The clinical pharmacist proposed to switch to doxycycline and clarithromycin with co-administration of magnesium isoglycyrrhizinate and polyene phosphatidylcholine to protect the liver. With this new regime, patient's liver function was improved and the infection was under control. Conclusion Individualized pharmaceutical cares provided by clinical pharmacists helped the safe, rational and effective use of medications.
