Stability study and manufacture process optimization for Zhibai Anshen oral liquid
10.12206/j.issn.1006-0111.202009046
- VernacularTitle:知百安神口服液制备工艺优化及稳定性研究
- Author:
Huihua YU
1
;
Jingxian LI
2
;
Chunxia JIANG
2
;
Tao PANG
2
;
Wansheng CHEN
2
;
Shujuan PIAO
2
Author Information
1. Naval Medical University: Depatment of Pharmacy, Changhai Hospital, Shanghai 200433, China.
2. Depatment of Pharmacy, Changzheng Hospital, Shanghai 200003, China.
- Keywords:
Zhibai Anshen oral liquid;
mangiferin;
manufacture process
- From:
Journal of Pharmaceutical Practice
2021;39(6):549-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the manufacture process for Zhibai Anshen oral liquid. Methods The orthogonal designed experiments were conducted to monitor the effects of three factors on the content of mangiferin. The three factors included the amount of water, extraction time and alcohol precipitation concentration. Six month accelerated stability study and twelve month long term stability study were performed. Results Optimum percolation process was boiling the mixture with 10 times of water for 1 hour, followed by deposition with 60% alcohol. Conclusion This optimized process can be used for mass production.
