Synthesis method optimization and biodistribution study of <sup>18</sup>F-T807 on TRACERlab FX<sub>FN</sub> synthesizer

VernacularTitle:¹⁸F-T807在TRACERlab FX_FN合成器上合成方法的优化及生物分布研究
Author: Feng ZUO ¹ ; Hua HUO ¹ ; Zhiguo WANG ¹ ; Guoxu ZHANG ¹ ; Qingxue SHI ¹ ; Zongpeng ZHANG ¹
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Keywords: T807; tau protein; radiopharmaceutical; PET
From: Journal of Pharmaceutical Practice 2021;39(6):525-528
CountryChina
Language:Chinese
Abstract: Objective To optimize the synthesis method of ¹⁸F-T807 and study preliminary biodistribution. Methods ¹⁸F-T807 was synthesized using an optimized method in TRACERlab FX_FN synthesizer with a t-BOC（t-Butyloxy carbonyl）-protected ¹⁸F-T807 precursor NPPI-9 as starting material, improving experimental conditions for synthesis, then QC and biodistribution study in Wistar rats conducted. Results The improved synthesis conditions increased the synthesis yield from 20.5%±6.1% to 25.7%±5.8%. QC met the standard. Wistar rats had higher intake in kidney, liver, blood and lowest intake in brain, heart, lung. Conclusion The optimized synthesis method to synthesize ¹⁸F-T807 is simple and easy, and high yield, which can meet the needs of scientific research and clinical practice.