Role of cGAS-cGAMP-STING pathway in antivirus

VernacularTitle:cGAS-cGAMP-STING通路在抗病毒中的作用
Author: Qian ZHANG ^{1
,

2} ; Yuefan ZHANG ³ ; Tiejun LI ^{1
,

2}
Author Information

1. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
2. Shanghai Punan Hospital of Pudong New Area, Shanghai 200125, China.
3. School of Medicine, Shanghai University, Shanghai 200444, China.
Keywords: cGAS; cGAMP; STING; antivirus
From: Journal of Pharmaceutical Practice 2021;39(6):487-490
CountryChina
Language:Chinese
Abstract: Innate immunity is the host's first line defense against pathogens invading to the body. Detection of abnormal nucleic acids in the cytoplasm showed that some conserved pathogen associated molecular patterns (PAMPS) triggered type I interferon (IFN) -mediated innate immune responses. The DNA sensor— cGAS (cGAMP Synthase) recognizes and binds to host or pathogen cytoplasmic DNA, promotes the formation of the second messenger cGAMP (cyclic GMP-AMP), and triggers STING (stimulator of interferon genes) dependent downstream signaling. Here we briefly describe the latest progress of the cGAS-cGAMP-STING pathway and its important role in antivirus, and provide new ideas for virus prevention research and new direction for the development of antiviral drugs.