Internal relationship between Hippo pathway and pulmonary hypertension
10.7507/1007-4848.202011001
- VernacularTitle:Hippo 通路与肺高血压的关系
- Author:
Zhiruo SONG
1
,
2
;
Hong QIAN
3
Author Information
1. 1. Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
2. 2. West China School of Medicine, Sichuan University, Chengdu, 610041, P.R.China
3. Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
- Publication Type:Journal Article
- MeSH:
Pulmonary hypertension;
Hippo pathway;
pulmonary vascular remodeling;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2021;28(11):1376-1380
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary hypertension is a kind of progressive pulmonary vascular diseases in which there is excessive vasoconstriction and abnormal pulmonary vascular remodeling, and then a gradual increase in pulmonary arterial pressure, and it eventually leads to right ventricular failure and even death. The pathogenesis of pulmonary hypertension is still uncertain, but some studies suggest that Hippo pathway or some components of the Hippo pathway may be involved in the progress of pulmonary hypertension. In this review, we describe the mechanism of the Hippo pathway or some components of the Hippo pathway in the progress of pulmonary hypertension.
