Comparison of segmentectomy versus lobectomy for ≤2 cm lung adenocarcinoma with micropapillary and solid subtype negative by intraoperative frozen sections: A multi-center randomized controlled trial

Chang Chen; Yuming Zhu; Gening Jiang; Haifeng Wang; Dong Xie; Hang SU; Long XU; Deping Zhao; Liang Duan; Boxiong Xie; Chunyan WU; Likun Hou; Huikang Xie; Junqiang Fan; Xuedong Zhang; Weirong Shi; Honggang KE; Lei Zhang; Hao Wang; Xuefei HU; Qiankun Chen; Lei Jiang; Wenxin HE; Yiming Zhou; Xiong Qin; Xiaogang Zhao; Hongcheng Liu; Peng Zhang; Yang Yang; Ming Liu; Hui Zheng

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Comparison of segmentectomy versus lobectomy for ≤2 cm lung adenocarcinoma with micropapillary and solid subtype negative by intraoperative frozen sections: A multi-center randomized controlled trial

VernacularTitle:肺段切除术和肺叶切除术治疗直径≤2 cm 且术中冰冻证实微乳头和实性亚型阴性肺腺癌的多中心随机对照研究
Author: Chang CHEN ¹ ; Yuming ZHU ¹ ; Gening JIANG ¹ ; Haifeng WANG ¹ ; Dong XIE ¹ ; Hang SU ¹ ; Long XU ¹ ; Deping ZHAO ¹ ; Liang DUAN ¹ ; Boxiong XIE ¹ ; Chunyan WU ² ; Likun HOU ² ; Huikang XIE ² ; Junqiang FAN ³ ; Xuedong ZHANG ^{4
,

5} ; Weirong SHI ^{4
,

5} ; Honggang KE ⁶ ; Lei ZHANG ¹ ; Hao WANG ¹ ; Xuefei HU ¹ ; Qiankun CHEN ¹ ; Lei JIANG ¹ ; Wenxin HE ¹ ; Yiming ZHOU ¹ ; Xiong QIN ¹ ; Xiaogang ZHAO ¹ ; Hongcheng LIU ¹ ; Peng ZHANG ¹ ; Yang YANG ¹ ; Ming LIU ¹ ; Hui ZHENG ¹
Author Information

1. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, P.R.China
2. Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, P.R.China
3. Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, P.R.China
4. Department of Thoracic Surgery, The Sixth People'
5. s Hospital of Nantong, Shanghai University, Nantong, 216002, Jiangsu, P.R.China
6. Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, P.R.China
Publication Type:Journal Article
Keywords: Segmentectomy; lobectomy; micropapillary; solid; lung adenocarcinoma; randomized controlled trial
From: Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2021;28(11):1292-1298
CountryChina
Language:Chinese
Abstract: Objective To compare the clinical effects of segmentectomy and lobectomy for ≤2 cm lung adenocarcinoma with micropapillary and solid subtype negative by intraoperative frozen sections. Methods The patients with adenocarcinoma who received segmentectomy or lobectomy in multicenter from June 2020 to March 2021 were included. They were divided into two groups according to a random number table, including a segmentectomy group (n=119, 44 males and 75 females with an average age of 56.6±8.9 years) and a lobectomy group (n=115, 43 males and 72 females with an average of 56.2±9.5 years). The clinical data of the patients were analyzed. Results There was no significant difference in the baseline data between the two groups (P>0.05). No perioperative death was found. There was no statistical difference in the operation time (111.2±30.0 min vs. 107.3±34.3 min), blood loss (54.2±83.5 mL vs. 40.0±16.4 mL), drainage duration (2.8±0.6 d vs. 2.6±0.6 d), hospital stay time (3.9±2.3 d vs. 3.7±1.1 d) or pathology staging (P>0.05) between the two groups. The postoperative pulmonary function analysis revealed that the mean decreased values of forced vital capacity and forced expiratory volume in one second percent predicted in the segmentectomy group were significantly better than those in the lobectomy group (0.2±0.3 L vs. 0.4±0.3 L, P=0.005; 0.3%±8.1% vs. 2.9%±7.4%, P=0.041). Conclusion Segmentectomy is effective in protecting lungs function, which is expected to improve life quality of patients.