Progress on biomarkers of EB virus-related posttransplant lymphoproliferative disease
10.3969/j.issn.1674-7445.2021.06.019
- VernacularTitle:EB病毒相关性移植后淋巴组织增生性疾病生物标志物的相关进展
- Author:
Liang AI
1
;
Sheng ZHANG
;
Qiang WANG
;
Xia LI
;
Ke CHENG
Author Information
1. Department of Transplant Surgery, the Third Xiangya Hospital, Central South University, Changsha 410013, China
- Publication Type:Research Article
- Keywords:
Epstein-Barr virus (EBV);
Organ transplantation;
Posttransplant lymphoproliferative disease (PTLD);
B-cell lymphoma;
Biomarker;
Immune suppression;
Virus load;
Micro RNA
- From:
Organ Transplantation
2021;12(6):767-
- CountryChina
- Language:Chinese
-
Abstract:
Posttransplant lymphoproliferative disease (PTLD) is a series of heterogeneous lymphoproliferative diseases and a severe complication after solid organ transplantation in children. Over 70% of PTLD is associated with Epstein-Barr virus (EBV). EBV-related B-cell lymphoma is also the main malignant tumor after pediatric organ transplantation. EBV-related PTLD is still a challenge in pediatric solid organ transplantation, which is mainly caused by immune function damage induced by immune suppression after transplantation. However, the specific mechanism remains elusive. In recent years, biomarkers have been developed to guide the diagnosis and individualized treatment of EBV-related PTLD, which possesses excellent application prospect. In this article, research progresses on the incidence of EBV-related PTLD in solid organ transplantation and its biomarkers were reviewed, aiming to explore novel ideas for clinical diagnosis and treatment.
