Recent progress on the roles of DAMP and NET in organ ischemia-reperfusion injury
10.3969/j.issn.1674-7445.2021.06.018
- VernacularTitle:DAMP与NET在器官缺血-再灌注损伤中作用新进展
- Author:
Zhirui ZOU
1
;
Jiangwei MAN
;
Li YANG
Author Information
1. Department of Urology, Lanzhou University Second Hospital, Lanzhou 730000, China
- Publication Type:Research Article
- Keywords:
Ischemia-reperfusion injury (IRI);
Damage-associated molecular pattern (DAMP);
Neutrophil extracellular trap (NET);
Aseptic inflammation;
Toll-like receptor (TLR);
Mitochondrial DNA (mtDNA);
Extracellular cold-inducible RNA-binding protein (eCIRP);
High mobility group box 1 (HMGB1)
- From:
Organ Transplantation
2021;12(6):761-
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon, secondary to multiple pathological processes, such as organ transplantation, acute kidney injury and myocardial infarction. IRI may significantly aggravate the severity of diseases and increase the fatality of patients. Aseptic inflammation is one of the critical mechanisms of IRI. Damage-associated molecular pattern (DAMP) is a pivotal substance, which mediates aseptic inflammation. After released into extracellular space, it could effectively activate the immune system, and initiate and maintain the inflammatory responses by binding with pattern recognition receptor (PRR). Neutrophil extracellular trap (NET) is a DNA-based network structure released by neutrophils during the process of inflammatory responses, which contains histones and multiple granular proteins. Recent studies have demonstrated that DAMP and NET may aggravate IRI via aseptic inflammation. In this article, relevant studies of DAMP, NET and their relationship in IRI were reviewed, which was of great significance for understanding the pathophysiological mechanism of IRI and studying the corresponding prevention and treatment strategies.
