Diagnostic criteria and research progress on heart allograft pathology
10.3969/j.issn.1674-7445.2021.06.004
- VernacularTitle:移植心脏病理学诊断标准及其进展
- Author:
Hui GUO
1
Author Information
1. Organ Transplantation Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation of Ministry of Education, Key Laboratory of Organ Transplantation of National Health Commission of China, Key Laboratory of Organ Transplantation of Chinese Academy of Medical Sciences, Wuhan 430030, China
- Publication Type:Research Article
- Keywords:
Endomyocardial biopsy(EMB);
Acute cellular rejection (ACR);
T cell-mediated rejection (TCMR);
Antibody-mediated rejection (AMR);
Transplant coronary artery disease (TCAD);
Next-generation sequencing(NGS);
Gene expression profile (GEP);
Donor-derived cell-free DNA (dd-cfDNA)
- From:
Organ Transplantation
2021;12(6):662-
- CountryChina
- Language:Chinese
-
Abstract:
With the improvement of surgical technique of heart transplantation and clinical application of potent immunosuppressant, the quantity of heart transplantation and the survival time of heart allograft have been significantly improved. However, a series of complications, such as right ventricular failure, ischemia-reperfusion injury, acute rejection, "Quilty lesion", infection and chronic rejection characterized by transplant coronary artery disease (TCAD) may still occur at different stages after heart transplantation. The application of endomyocardial biopsy (EMB) makes it possible to observe and understand the pathological features of multiple complications of heart allograft including rejection, which has become the most accurate diagnostic tool for postoperative complications. In this article, the brief history of heart allograft pathology, main postoperative complications and pathological diagnostic criteria, and cutting edge research progress on diagnostic criteria of rejection were illustrated, aiming to bring clinical benefits to more recipients undergoing heart transplantation.
