Performance of three commercial rapid diagnostic tests for the detection of hepatitis B surface antigen (HBs Ag) in Lao PDR
- Author:
Dalouny Sihalath
1
;
Philavanh Sitbounlang
2
;
Sengdao Vannarath
1
;
Bouachanh Rasachak
1
;
Myfong Mayxay
3
;
Stéphane Bertani
4
;
Eric Deharo
4
;
Phimpha Paboriboune
5
Author Information
1. Gastroenterology department, Mohosot Hospital, Vientiane, Laos
2. Centre de Infectiologie Lao-Christophe Mrrieux, Vientiane, Laos
3. Faculty of Postgraduate Studies, University of Health Sciences, Vientiane, Laos
4. Universite de Toulouse, IRD, UPS, UMR 152 PHARMADEV, Toulouse, France
5. Centre de Infectiologie Lao-Christophe Merieux, Vientiane, Laos
- Publication Type:Journal Article
- Keywords:
Hepatitis B, ELISA, Laos, rapid diagnostic test
- From:
Lao Medical Journal
2021;12(12):53-58
- CountryLao People's Democratic Republic
- Language:English
-
Abstract:
Objective:This study aimed to determine sensitivity, specificity, and accuracy of RDT used in 4 health care centres in Vientiane capital versus ELISA.
Methods:A study was then conducted among 1,729 patients who underwent three different RDTs for surface antigen of hepatitis virus (Boson, CTK and Coretest) in two public central hospitals and two private clinics in Vientiane Capital, to compare sensitivity, specificity, and accuracy of RDTs versus ELISA.
Results:The mean age (95%CI) of the patients was 28.7 years old and the sex ratio was balanced. 13.71% of the patients had positive HBsAg as detected by ELISA, while this was only 8.9% for RDTs. All three types of RDTs had a sensitivity of 54% and specificity of 97%. There was no difference in accuracy, sensitivity, specificity, positive and negative predictive values between RDTs.
Conclusions:This study revealed higher prevalence of HBsAg among young adults who were present in health care facilities in Vientiane than previously described in Laos. All three RDTs studied had low sensitivity but high specificity; therefore, they are likely to miss many cases of Hepatitis B infection and should be replaced or backed up by more accurate methods.
- Full text:7.Performance of RDTs vs ELISA for AgHbs detection_PP 15.08.21.pdf
