Overview of the Systematic Review of Drug Treatment for Tic Disorders in Children
- VernacularTitle:药物治疗儿童抽动障碍的系统评价再评价
- Author:
Jianhua ZHANG
1
,
2
;
Bingyao KANG
1
,
2
;
Dan LI
1
,
2
;
Dan LUO
1
,
2
;
Chunsong YANG
2
,
3
;
Jing CHEN
2
Author Information
1. Nursing Unit of Pediatric Outpatient，West China Second Hospital，Sichuan University，Chengdu 610041，China
2. Key Laboratory of Birth Defects and Related Diseases of Women and Children，Sichuan University，Ministry of Education，Chengdu 610041，China
3. Dept. of Pharmacy/Evidence-based Pharmacy Center，West China Second Hospital，Sichuan University，Chengdu 610041，China
- Publication Type:Journal Article
- Keywords:
Tic disorder;
Medication;
Systematic review
- From:
China Pharmacy
2021;32(21):2647-2654
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To overview and analyze the current evidence of systematic reviews of drug treatment for children with tic disorder （TD），and to provide evidence-based reference for clinical practice. METHODS ：Retrieved from Medline ，Embase， CBM，CNKI，VIP and Wanfang database ，and so on ，systematic reviews about the efficacy and safety of drug treatment for TD were collected. AMSTAR- 2 tools were used to evaluate the quality of included studies ；the intervention measures ，diagnosis standard，outcome index ，the types of included studies ，main conclusion ，control measures ，effect sizes of different drug treatment were also extracted and analyzed descriptively. RESULTS ：A total of 27 systematic reviews were included ，of which 5 were medium-quality，8 low-quality and 14 very-low-quality. Meta-analysis showed that although typical psychiatric drugs could control tic symptoms ，ADR were prominent and the safety was not good ；risperidone and aripiprazole as atypical psychiatric drugs had good efficacy and safety ，and the research evidence was relatively sufficient. Clonidine as α2 adrenergic agonist could effectively control tic symptoms with fewer ADR ，especially for patients with affention deficit and hyperactivity disorder （ADHD），and research evidence was sufficient. Tiapride could effectively improve tic symptoms ，and the overall tolerance was better. Tomoxetine and methylphenidate could significantly improve the tic symptoms of tic patients with ADHD. CONCLUSIONS ：In the clinical treatment of TD in children ，ADR induced by typical antipsychotics are prominent and the safety is not good ；risperidone， aripiprazole，clonidine and tiapride have good efficacy and safety. Clonidine ，tomoxetine and methylphenidate could significantly improve tic symptoms of TD patients with ADHD. But the quality of systematic review methodology for tomoxetine and methylp- henidate is not good and further improvement is needed.
